Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.83 |
| ▸ | HTR1A | P08908 | 6/20 | 0.83 |
| ▸ | HTR1D | P28221 | 3/20 | 0.83 |
| ▸ | HTR1B | P28222 | 3/20 | 0.83 |
| ▸ | HTR2C | P28335 | 3/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.83 |
| ▸ | HTR7 | P34969 | 2/20 | 0.83 |
| ▸ | HTR6 | P50406 | 2/20 | 0.83 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.83 |
| ▸ | MAPT | P10636 | 1/20 | 0.83 |
| ▸ | TSHR | P16473 | 1/20 | 0.83 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.83 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.83 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.81 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.81 |
| ▸ | HTR2B | P41595 | 3/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9329737 | 0.96 | HTR2A (0.81) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL7819940 | 0.94 | HTR1A (0.79) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| 5-Methoxytryptamine SCHEMBL41982 | 0.91 | HTR1A (1.00) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| 5-Methoxytryptamine SCHEMBL29390103 | 0.91 | HTR1A (1.00) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| 5-Methoxytryptamine SCHEMBL130877 | 0.90 | HTR1A (0.97) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| 5-Methoxytryptamine SCHEMBL31109114 | 0.90 | NPSR1 (1.00) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| 5-Methoxytryptamine SCHEMBL1322980 | 0.90 | NPSR1 (1.00) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| 5-Methoxytryptamine SCHEMBL26617456 | 0.90 | HTR1A (0.97) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| SCHEMBL5023884 | 0.88 | HTR2A (0.83) | HTR2AHTR1AHTR1DHTR1BHTR2C | |
| 5-Methoxytryptamine SCHEMBL28681558 | 0.87 | HTR1A (0.91) | HTR2AHTR1AHTR1DHTR1BHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056610-C | Piperidines and piperazines | MERCK PATENT GMBH (DE) | 2000-09-20 | — | — | CN | disclosed |
| EP-0745586-B1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-08 | — | — | EP | disclosed |
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |
| EP-0745586-A1 | Aryl(alkyl) propylamides, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |
| CN-1106811-A | Piperidines and piperazines | MERCK PATENG GES MIT BESCHRAEN (DE) | 1995-08-16 | — | — | CN | disclosed |