Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 5-Methoxytryptamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 9/20 | 0.97 |
| ▸ | HTR1B known ✓ | P28222 | 8/20 | 0.97 |
| ▸ | HTR1D known ✓ | P28221 | 7/20 | 0.97 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.97 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.97 |
| ▸ | HTR7 known ✓ | P34969 | 2/20 | 0.97 |
| ▸ | HTR6 known ✓ | P50406 | 2/20 | 0.97 |
| ▸ | HTR4 known ✓ | Q13639 | 2/20 | 0.97 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.75 |
| ▸ | HTR3E known ✓ | A5X5Y0 | 1/20 | 0.68 |
| ▸ | HTR3B known ✓ | O95264 | 1/20 | 0.68 |
| ▸ | HTR1E known ✓ | P28566 | 1/20 | 0.68 |
| ▸ | HTR1F known ✓ | P30939 | 1/20 | 0.68 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.68 |
| ▸ | HTR5A known ✓ | P47898 | 1/20 | 0.68 |
| ▸ | HTR3D known ✓ | Q70Z44 | 1/20 | 0.68 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 1/20 | 0.68 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 5-Methoxytryptamine SCHEMBL31109114 | 1.00 | NPSR1 (1.00) | NPSR1BLMPMP22HTR1AHTR1B | |
| 5-Methoxytryptamine SCHEMBL41982 | 0.98 | HTR1A (1.00) | NPSR1BLMPMP22HTR1AHTR1B | |
| 5-Methoxytryptamine SCHEMBL29390103 | 0.98 | HTR1A (1.00) | NPSR1BLMPMP22HTR1AHTR1B | |
| 5-Methoxytryptamine SCHEMBL130877 | 0.97 | HTR1A (0.97) | NPSR1BLMPMP22HTR1AHTR1B | |
| 5-Methoxytryptamine SCHEMBL26617456 | 0.97 | HTR1A (0.97) | NPSR1BLMPMP22HTR1AHTR1B | |
| 5-Methoxytryptamine SCHEMBL28309973 | 0.94 | HTR1A (0.91) | NPSR1BLMPMP22HTR1AHTR1B | |
| 5-Methoxytryptamine SCHEMBL28681558 | 0.94 | HTR1A (0.91) | NPSR1BLMPMP22HTR1AHTR1B | |
| 5-Methoxytryptamine SCHEMBL27863884 | 0.93 | HTR1A (0.89) | NPSR1BLMPMP22HTR1AHTR1B | |
| 5-Methoxytryptamine SCHEMBL27863882 | 0.92 | HTR1A (0.86) | NPSR1BLMPMP22HTR1AHTR1B | |
| Hydrochloric Acid SCHEMBL8869924 | 0.92 | NPSR1 (0.84) | NPSR1BLMPMP22HTR1AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 138 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115433164-A | Nicotinamide derivative, preparation method thereof and application thereof in anti-aging and life prolonging | 南京师范大学 | 2022-12-06 | — | — | CN | claimed |
| CN-108558732-A | A kind of indole amides class compound of alternative treatment gastric cancer and cervical carcinoma | 南华大学 | 2018-09-21 | — | — | CN | claimed |
| CN-106633969-A | Acrylic fiber-reinforced wood-plastic composite material and preparation method thereof | 苏州佰思科节能环保科技有限公司 | 2017-05-10 | — | — | CN | claimed |
| CN-106432953-A | High-strength PVC wood-plastic composite and preparation method thereof | 苏州佰思科节能环保科技有限公司 | 2017-02-22 | — | — | CN | claimed |
| CN-106277579-A | The deep treatment method of cultivation factory sewage | 吴小慧 | 2017-01-04 | — | — | CN | claimed |
| EP-1897881-A2 | Compounds useful for the treatment of obesity, type II diabetes and CNS disorders | Biovitrum AB (publ) (SE) | 2008-03-12 | — | — | EP | claimed |
| WO-2006099274-A1 | DIETARY SUPPLEMENT AND METHOD OF USING SAME | WHEAT JARED (US) | 2006-09-21 | — | — | WO | claimed |
| US-20060204599-A1 | Dietary supplement and method of using same | WHEAT JARED R | 2006-09-14 | — | — | US | claimed |
| EP-1513828-A1 | NEW COMPOUNDS USEFUL FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS DISORDERS | Biovitrum AB (SE) | 2005-03-16 | — | — | EP | claimed |
| US-20040024210-A1 | New compounds | PROXIMAGEN NEUROSCIENCE PLC (GB) | 2004-02-05 | — | — | US | claimed |
| WO-2004000828-A1 | NEW COMPOUNDS USEFUL FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS DISORDERS | BIOVITRUM AB (SE) | 2003-12-31 | — | — | WO | claimed |
| US-20020173511-A1 | Serotonergic compositions and methods for treatment of mild cognitive impairment | WURTMAN RICHARD J (US) | 2002-11-21 | — | — | US | claimed |
| WO-2002038142-A2 | SEROTONERGIC COMPOSITIONS AND METHODS FOR TREATMENT OF MILD COGNITIVE IMPAIRMENT | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-05-16 | — | — | WO | claimed |
| JP-1045363-A | — | — | None | — | — | JP | disclosed |
| CN-118290427-A | N-substituted pyrazolo [3,4-d ] pyrimidinone compound and application thereof | 中山大学 | 2024-07-05 | — | — | CN | disclosed |
| EP-4288048-A1 | OXA-IBOGAINE INSPIRED ANALOGUES FOR TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | The Trustees Of Columbia University In The City Of New York (US) | 2023-12-13 | — | — | EP | disclosed |
| EP-0130303-A1 | Process for separation of serotonine | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 1985-01-09 | — | — | EP | disclosed |
| US-4277476-A | ANTI-ANOXIA AND PSYCHOTROPIC AGENTS | SYNTHELABO (FR) | 1981-07-07 | — | — | US | disclosed |
| US-4107175-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1978-08-15 | — | — | US | disclosed |
| US-4104467-A | ANTIINFLAMMATORY | E. R. SQUIBB & SONS, INC. (US) | 1978-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040024210-A1 | New compounds | SULT1E1, SULT2A1, SULT1A1 | HTR1A 1317/4885HTR1B 452/4885HTR1D 1478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.