Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902318 | 0.72 | NPC1 (0.46) | MCHR1NPBWR1KMT2ASMN1; SMN2HTT | |
| SCHEMBL4192879 | 0.70 | PTGS2 (0.48) | MCHR1NPBWR1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL2897589 | 0.69 | MPO (0.44) | MCHR1NPBWR1PKMSMN1; SMN2HTT | |
| SCHEMBL4190082 | 0.69 | CHRNA7 (0.48) | MCHR1NPBWR1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL12059470 | 0.64 | MCHR1 (0.53) | MCHR1 | |
| SCHEMBL13219324 | 0.61 | ALDH1A1 (0.66) | MCHR1NPBWR1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL4136494 | 0.61 | NPC1 (0.75) | MCHR1NPBWR1PKMKMT2ASMN1; SMN2 | |
| SCHEMBL2222115 | 0.60 | CNR2 (0.40) | MCHR1SMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL5558900 | 0.60 | RAB9A (0.53) | MCHR1NPBWR1KMT2ASMN1; SMN2HTT | |
| SCHEMBL4189818 | 0.60 | NPBWR1 (0.51) | MCHR1NPBWR1PKMKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124804-A1 | PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000024719-A1 | PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE BIOSYNTHESIS INHIBITORS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |