Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 12/20 | 0.40 |
| ▸ | MMP9 | P14780 | 12/20 | 0.40 |
| ▸ | MMP1 | P03956 | 11/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572045 | 0.92 | PTGS2 (0.41) | PTGS2MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7820104 | 0.87 | MMP13 (0.45) | PTGS2MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7316088 | 0.87 | MMP13 (0.45) | PTGS2MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7453436 | 0.85 | MMP13 (0.58) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7312722 | 0.85 | MMP13 (0.58) | MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7830182 | 0.83 | TRPM8 (0.48) | MMP13MMP9MMP1ADAM17MMP12 | |
| SCHEMBL7825679 | 0.83 | MMP13 (0.44) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7820004 | 0.83 | TAS1R3 (0.43) | PTGS2MMP13MMP9MMP1ADAM17 | |
| SCHEMBL7322130 | 0.80 | MMP13 (0.47) | MMP13MMP9MMP1ADAM17MMP3 | |
| SCHEMBL7453309 | 0.80 | MEN1 (0.44) | PTGS2MMP13MMP9MMP1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0938471-B1 | THE PREPARATION AND USE OF ORTHO-SULFONAMIDO ARYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE AND TACE INHIBITORS | AMERICAN CYANAMID CO (US) | 2001-12-12 | — | — | EP | claimed |