Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30195050 | 0.89 | SMN1; SMN2 (0.42) | RAB9ASMN1; SMN2NPC1L3MBTL1KMT2A | |
| SCHEMBL27454856 | 0.84 | KMT2A (0.42) | KMT2AHPGDDAOALDH1A1LMNA | |
| SCHEMBL27429798 | 0.82 | CTRC (0.53) | NR1H2RAB9ASMN1; SMN2NPC1L3MBTL1 | |
| SCHEMBL10425151 | 0.76 | ELANE (0.39) | RAB9ASMN1; SMN2NPC1L3MBTL1KMT2A | |
| SCHEMBL16823391 | 0.74 | CA1 (0.44) | L3MBTL1KMT2AALDH1A1CA1CA9 | |
| SCHEMBL55137 | 0.73 | HTR1A (0.58) | NR1H2SMN1; SMN2NR1H3HTR1ADRD2 | |
| SCHEMBL28413724 | 0.73 | CTRC (0.43) | NR1H2RAB9ANR1H3NPC1L3MBTL1 | |
| SCHEMBL8661882 | 0.73 | PTGS2 (0.49) | RAB9ASMN1; SMN2NPC1L3MBTL1GPR52 | |
| SCHEMBL981305 | 0.73 | — | — | |
| SCHEMBL719865 | 0.71 | L3MBTL1 (0.46) | RAB9ASMN1; SMN2NPC1L3MBTL1GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1142887-A1 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents | PARKE, DAVIS & COMPANY (US) | 2001-10-10 | — | — | EP | disclosed |
| EP-0729464-A1 | 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0729463-A1 | 5,6-DIHYDROPYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |