SCHEMBL782140

SCHEMBL782140

CNC(=O)c1cc(Cl)cc(Cl)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.86

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.42
MALT1 Q9UDY8 3/20 0.37
NTRK1 P04629 5/20 0.35
EPHX2 P34913 1/20 0.34
KMT2A Q03164 1/20 0.34
PSD A5PKW4 1/20 0.34
RBP4 P02753 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28517966 0.93 DHODH (0.41) DHODHMALT1NTRK1EPHX2KMT2A
Chlorantraniliprole SCHEMBL29551 0.93 DHODH (0.44) DHODHMALT1NTRK1PSD
Chlorantraniliprole SCHEMBL29363261 0.93 DHODH (0.44) DHODHMALT1NTRK1PSD
SCHEMBL10140197 0.93 DHODH (0.41) DHODHMALT1NTRK1EPHX2KMT2A
SCHEMBL12574921 0.92 DHODH (0.43) DHODHMALT1KMT2APSDRBP4
SCHEMBL28867319 0.90 DHODH (0.41) DHODHMALT1KMT2APSDRBP4
SCHEMBL28957021 0.90 DHODH (0.41) DHODHMALT1NTRK1PSD
SCHEMBL782242 0.90 MALT1 (0.38) DHODHMALT1NTRK1EPHX2KMT2A
SCHEMBL782468 0.90 DHODH (0.41) DHODHRBP4
SCHEMBL31256508 0.90 DHODH (0.41) DHODHRBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 155 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10405548-B2 Fungicidal compositions SYNGENTA CROP PROTECTION LLC (US) 2019-09-10 US disclosed
EP-2547665-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-07-04 EP disclosed
US-9949482-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2018-04-24 US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
US-20170071205-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2017-03-16 US disclosed
US-20170027173-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, LLC (US) 2017-02-02 US disclosed
US-20170027173-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, LLC (US) 2017-02-02 US disclosed
EP-2723723-B1 N-OXY PYRAZOLO-TRIAZEPINE-DIONE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-02-01 EP disclosed
US-9499524-B2 Insecticidal compounds SYNGENTA PARTICIPATIONS AG (CH) 2016-11-22 US disclosed
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2008-01-31 US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 US disclosed
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-11-22 US disclosed
US-20070244073-A1 Pesticidal Mixtures SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed
US-20070244073-A1 Pesticidal Mixtures SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
WO-2007020050-A2 BICYCLIC BISAMIDE DERIVATIVES AND USE THEREOF AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-02-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070142327-A1 Active compound combinations having insecticidal properties ACHE, ANTXR2, NANP DHODH 2787/4885MALT1 4112/4885NTRK1 4461/4885
US-20170027173-A1 INSECTICIDAL COMPOUNDS ACHE, AADAC, CASP3 DHODH 1693/4885MALT1 3632/4885NTRK1 4863/4885
US-20080027114-A1 Active Agent Combinations with Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS DHODH 2032/4885MALT1 3859/4885NTRK1 4548/4885
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties ACHE, CHRM3, CHRNA2 DHODH 3666/4885MALT1 4862/4885NTRK1 1175/4885
US-20070270416-A1 Active Compound Combinations Having Insecticidal and Acaricidal Properties AADAC, ACAA2, AAAS DHODH 2064/4885MALT1 4117/4885NTRK1 4584/4885
US-20070244073-A1 Pesticidal Mixtures ACHE, ATL3, BPHL DHODH 2761/4885MALT1 4817/4885NTRK1 4780/4885
US-10405548-B2 Fungicidal compositions PIK3C3, CYP51A1, CYP1B1 DHODH 874/4885MALT1 1035/4885NTRK1 4812/4885
US-20170071205-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 DHODH 874/4885MALT1 1035/4885NTRK1 4812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.