SCHEMBL782242

SCHEMBL782242

CNC(=O)c1cc(Cl)cc(Cl)c1NC(=O)c1cc(Cl)nn1-c1ncccc1Cl

nearest known ligand 0.70

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MALT1 Q9UDY8 5/20 0.38
NTRK1 P04629 5/20 0.35
EPHX2 P34913 1/20 0.35
KMT2A Q03164 1/20 0.35
DHODH Q02127 2/20 0.34
TRPV1 Q8NER1 1/20 0.34
RBP4 P02753 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL782485 0.92 MALT1 (0.39) MALT1NTRK1KMT2ADHODHTRPV1
SCHEMBL10140227 0.92 TRPV1 (0.36) MALT1NTRK1EPHX2KMT2ADHODH
SCHEMBL12528237 0.91 NTRK1 (0.39) MALT1NTRK1KMT2A
SCHEMBL11893200 0.91 DHODH (0.37) MALT1KMT2ADHODHTRPV1RBP4
SCHEMBL782140 0.90 DHODH (0.42) MALT1NTRK1EPHX2KMT2ADHODH
SCHEMBL12935676 0.90 MALT1 (0.37) MALT1NTRK1EPHX2KMT2ADHODH
SCHEMBL782499 0.89 CNR1 (0.36) MALT1KMT2ADHODHRBP4
SCHEMBL10028759 0.89 CHIA (0.40) NTRK1KMT2A
SCHEMBL7128492 0.89 MALT1 (0.35) MALT1NTRK1DHODH
SCHEMBL959805 0.89 KMT2A (0.36) MALT1NTRK1KMT2ADHODHTRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210378242-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2021-12-09 US disclosed
US-10405548-B2 Fungicidal compositions SYNGENTA CROP PROTECTION LLC (US) 2019-09-10 US disclosed
EP-2547665-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-07-04 EP disclosed
US-9949482-B2 Fungicidal compositions SYNGENTA CROP PROTECTION, LLC (US) 2018-04-24 US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
US-9771365-B2 Spiroheterocyclic N-oxypiperidines as pesticides SYNGENTA PARTICIPATIONS AG (CH) 2017-09-26 US disclosed
US-20170071205-A1 FUNGICIDAL COMPOSITIONS SYNGENTA CROP PROTECTION, LLC (US) 2017-03-16 US disclosed
US-20170027173-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, LLC (US) 2017-02-02 US disclosed
US-20170027173-A1 INSECTICIDAL COMPOUNDS SYNGENTA CROP PROTECTION, LLC (US) 2017-02-02 US disclosed
EP-2723723-B1 N-OXY PYRAZOLO-TRIAZEPINE-DIONE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2017-02-01 EP disclosed
US-20070244073-A1 Pesticidal Mixtures SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed
US-20070244073-A1 Pesticidal Mixtures SYNGENTA CROP PROTECTION, INC. (US) 2007-10-18 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-10-04 US disclosed
WO-2007093402-A1 PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE SYNGENTA PARTICIPATIONS AG (CH) 2007-08-23 WO disclosed
WO-2007080131-A2 ANTHRANILAMIDE DERIVATIVES AND THEIR USE FOR THE CONTROL OF INSECTS AND ACARI SYNGENTA PARTICIPATIONS AG (CH) 2007-07-19 WO disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
US-20070142327-A1 Active compound combinations having insecticidal properties BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2007-06-21 US disclosed
WO-2007020050-A2 BICYCLIC BISAMIDE DERIVATIVES AND USE THEREOF AS INSECTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-02-22 WO disclosed
WO-2007009661-A2 PESTICIDAL MIXTURES CONTAINING BICYCLIC ANTHRANILAMIDES SYNGENTA PARTICIPATIONS AG (CH) 2007-01-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210378242-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 MALT1 1035/4885NTRK1 4812/4885EPHX2 838/4885
US-20070142327-A1 Active compound combinations having insecticidal properties ACHE, ANTXR2, NANP MALT1 4112/4885NTRK1 4461/4885EPHX2 2481/4885
US-20170027173-A1 INSECTICIDAL COMPOUNDS ACHE, AADAC, CASP3 MALT1 3632/4885NTRK1 4863/4885EPHX2 703/4885
US-20070232598-A1 Combination of Active Substances with Insecticidal Properties ACHE, CHRM3, CHRNA2 MALT1 4862/4885NTRK1 1175/4885EPHX2 688/4885
US-20070244073-A1 Pesticidal Mixtures ACHE, ATL3, BPHL MALT1 4817/4885NTRK1 4780/4885EPHX2 2571/4885
US-10405548-B2 Fungicidal compositions PIK3C3, CYP51A1, CYP1B1 MALT1 1035/4885NTRK1 4812/4885EPHX2 838/4885
US-20170071205-A1 FUNGICIDAL COMPOSITIONS PIK3C3, CYP51A1, CYP1B1 MALT1 1035/4885NTRK1 4812/4885EPHX2 838/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.