Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | PTPRE | P23469 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.42 |
| ▸ | GLRB | P48167 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | TPMT | P51580 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695647 | 0.80 | CES2 (0.48) | PTPRCPTPN2PTPN1PTPRAPTPRB | |
| SCHEMBL1355541 | 0.78 | TDP1 (0.54) | PTPN1GLRA3GLRBTDP1RXRB | |
| SCHEMBL38809 | 0.78 | ALDH1A1 (0.57) | PTPN1GLRA3GLRBTDP1RXRB | |
| SCHEMBL29654078 | 0.78 | ALDH1A1 (0.57) | PTPN1GLRA3GLRBTDP1RXRB | |
| SCHEMBL4631399 | 0.78 | TDP1 (0.59) | GLRA3GLRBTDP1RXRBALDH1A1 | |
| SCHEMBL9139315 | 0.78 | CSNK2A1 (0.53) | GLRA3GLRBTDP1RXRBCYP1A2 | |
| SCHEMBL522679 | 0.76 | PTPN1 (0.55) | PTPRCPTPN2PTPN1PTPRAPTPRB | |
| SCHEMBL455239 | 0.76 | KEAP1 (0.50) | GLRA3GLRBTDP1RXRBCYP1A2 | |
| SCHEMBL14994077 | 0.76 | SMN1; SMN2 (0.59) | TSHRALDH1A1GRIK1CA1CA2 | |
| SCHEMBL460892 | 0.76 | KDM4E (0.57) | PTPN1GLRA3GLRBTDP1RXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0593285-B1 | Intermediates, and processes thereto, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines | LILLY CO ELI (US) | 2001-12-12 | — | — | EP | disclosed |
| US-5691349-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 1997-11-25 | — | — | US | disclosed |
| EP-0654032-B1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LTD (GB) | 1997-10-15 | — | — | EP | disclosed |
| EP-0654032-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS. | ZENECA LTD (GB) | 1995-05-24 | — | — | EP | disclosed |
| US-5382668-A | Processes for the preparation of 5,6-di-hydropyrrolo[2,3-d]pyrimidines | ELI LILLY AND COMPANY (US) | 1995-01-17 | — | — | US | disclosed |
| EP-0593285-A2 | Intermediates, and processes there to, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines | ELI LILLY AND COMPANY (US) | 1994-04-20 | — | — | EP | disclosed |
| US-5302722-A | 3-carboxy-pyrrole derivatives | ELI LILLY AND COMPANY (US) | 1994-04-12 | — | — | US | disclosed |
| WO-1994003451-A1 | QUINUCLIDINE DERIVATIVES AS SQUALENE SYNTHASE INHIBITORS | ZENECA LIMITED (GB) | 1994-02-17 | — | — | WO | disclosed |
| US-5254716-A | Intermediates, and processes thereto, for the preparation of 5,6-dihydropyrrolo[2,3-d]pyrimidines | ELI LILLY AND COMPANY (US) | 1993-10-19 | — | — | US | disclosed |