Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003073 | 0.80 | PDE1B (0.36) | LMNAPOLBTP53MEN1KMT2A | |
| SCHEMBL7003301 | 0.77 | ADORA2A (0.35) | LMNASMN1; SMN2TP53HTTMEN1 | |
| SCHEMBL7662109 | 0.73 | ADORA1 (0.48) | LMNATSHRMEN1KMT2AADORA3 | |
| SCHEMBL8567698 | 0.71 | ADORA1 (0.48) | LMNATSHRMEN1KMT2AADORA3 | |
| SCHEMBL7671571 | 0.70 | TLR7 (0.45) | LMNANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL7668666 | 0.70 | POLB (0.47) | LMNANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL8575326 | 0.67 | TSHR (0.49) | P2RX7LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8577964 | 0.65 | KDM4E (0.43) | P2RX7NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL7666412 | 0.63 | ADORA1 (0.51) | LMNATSHRMEN1KMT2AADORA3 | |
| SCHEMBL7095767 | 0.62 | HSP90AA1 (0.37) | P2RX7LMNANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | Boehringer Ingelheim Pharma KG (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065912-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-23 | — | — | WO | disclosed |