Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 2/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.32 |
| ▸ | SCNN1A | P37088 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | PNP | P00491 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003073 | 0.88 | PDE1B (0.36) | ADORA2APDE1APDE1BPDE1CMAPT | |
| SCHEMBL7822690 | 0.77 | P2RX7 (0.38) | MAPTLMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7662109 | 0.71 | ADORA1 (0.48) | ADORA2ALMNAMEN1KMT2A | |
| SCHEMBL8567698 | 0.69 | ADORA1 (0.48) | ADORA2ALMNAMEN1KMT2A | |
| SCHEMBL7671571 | 0.68 | TLR7 (0.45) | PDE1APDE1BPDE1CNPBWR1LMNA | |
| SCHEMBL6996678 | 0.67 | ABL1 (0.42) | MAPTSIRT5TYMSLMNAKDM4E | |
| SCHEMBL16028568 | 0.65 | ALDH1A1 (0.47) | MAPTLMNAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7665749 | 0.63 | ADORA2B (0.43) | ADORA2AMAPTSIRT1SIRT3SIRT5 | |
| SCHEMBL6996703 | 0.63 | SIRT1 (0.46) | ADORA2APDE1APDE1BPDE1CSIRT1 | |
| SCHEMBL34413 | 0.61 | IDO1 (0.67) | ALDH1A1HTTSMN1; SMN2IDO1AGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | disclosed |
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1087973-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | Boehringer Ingelheim Pharma KG (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-2000012511-A1 | IMIDAZOTRIAZOLOPYRIMIDINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-09 | — | — | WO | disclosed |
| WO-1999065912-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-23 | — | — | WO | disclosed |