Sugi Predict

Sugi Predict / Compounds / SCHEMBL782308

SCHEMBL782308

SCHEMBL782308

CCCn1c(=O)oc2ccc(B3OC(C)(C)C(C)(C)O3)cc21

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ LPL P06858 6/20 0.41
▸ LIPG Q9Y5X9 6/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ KMO O15229 2/20 0.40
▸ RAB9A P51151 3/20 0.39
▸ IDO1 P14902 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ NPC1 O15118 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ TMEM97 Q5BJF2 1/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ LMNA P02545 1/20 0.38
▸ POLB P06746 1/20 0.38
▸ TP53 P04637 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16475230 0.90 LPL (0.40) LPLLIPGALDH1A1IDO1MEN1
SCHEMBL30639699 0.90 LPL (0.40) LPLLIPGALDH1A1IDO1MEN1
SCHEMBL26614707 0.89 KMO (0.42) ALDH1A1KMORAB9AIDO1MEN1
SCHEMBL30639689 0.89 KMO (0.42) ALDH1A1KMORAB9AIDO1MEN1
SCHEMBL31758208 0.86 SIGMAR1 (0.45) ALDH1A1KMORAB9AIDO1MEN1
SCHEMBL31757667 0.86 ALDH1A1 (0.45) ALDH1A1KMORAB9AMEN1NPC1
SCHEMBL298215 0.84 MAPT (0.49) ALDH1A1KMORAB9AMEN1NPC1
SCHEMBL30639708 0.84 MIF (0.37) LPLLIPGALDH1A1KMOIDO1
SCHEMBL30639730 0.84 CSF1R (0.40) ALDH1A1KMORAB9AIDO1MEN1
SCHEMBL26614727 0.84 MIF (0.37) LPLLIPGALDH1A1KMOIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2430018-B1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYMTHASE INHIBITORS NOVARTIS AG (CH) 2013-07-03 — — EP disclosed
EP-2430018-B1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYMTHASE INHIBITORS NOVARTIS AG (CH) 2013-07-03 — — EP disclosed
US-8455522-B2 Benzoxazolone derivatives as aldosterone synthase inhibitors NOVARTIS AG (CH) 2013-06-04 — — US disclosed
US-8455522-B2 Benzoxazolone derivatives as aldosterone synthase inhibitors NOVARTIS AG (CH) 2013-06-04 — — US disclosed
US-8455522-B2 Benzoxazolone derivatives as aldosterone synthase inhibitors NOVARTIS AG (CH) 2013-06-04 — — US disclosed
US-20120071514-A1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2012-03-22 — — US disclosed
US-20120071514-A1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2012-03-22 — — US disclosed
US-20120071514-A1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2012-03-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071514-A1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS CYP11B2, CYP11B1, CYP21A2 LPL 1278/4885LIPG 1207/4885ALDH1A1 178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.