Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 7/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.52 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216251 | 0.91 | PARP1 (0.49) | MAOADYRK1APARP1TIPARPHSD17B10 | |
| SCHEMBL7829082 | 0.89 | CTSV (0.44) | MAOADYRK1ACTSVCTSLALDH1A1 | |
| SCHEMBL7827211 | 0.87 | HSD17B10 (0.51) | PARP1HSD17B10MAPTESR2CTSV | |
| SCHEMBL7826175 | 0.86 | MAOA (0.54) | MAOADYRK1APARP1ALDH1A1KDM4E | |
| SCHEMBL7826292 | 0.86 | KDM4E (0.47) | MAOADYRK1AHSD17B10ALDH1A1CYP1A2 | |
| SCHEMBL7824605 | 0.85 | CTSV (0.43) | MAOADYRK1ACTSVCTSLCYP2D6 | |
| SCHEMBL7823420 | 0.84 | DYRK1A (0.44) | MAOADYRK1AHSD17B10MAPTALDH1A1 | |
| SCHEMBL7826811 | 0.83 | ALDH1A1 (0.40) | MAOADYRK1AHSD17B10MAPTESR2 | |
| SCHEMBL7816229 | 0.83 | MAOA (0.47) | MAOACTSVCTSL | |
| SCHEMBL8068050 | 0.82 | XDH (0.48) | MAOAPARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |