SCHEMBL7826432

SCHEMBL7826432

CCCCC(C=O)(CC)C(C)Sc1ccccc1C(=O)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.36
ALDH1A1 P00352 3/20 0.34
TSHR P16473 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
RAB9A P51151 1/20 0.34
ABCB1 P08183 2/20 0.33
CNR2 P34972 1/20 0.33
CAPN1 P07384 1/20 0.33
KIF11 P52732 1/20 0.33
NAAA Q02083 1/20 0.33
AKR1C3 P42330 1/20 0.33
CCNE2 O96020 1/20 0.32
CCNE1 P24864 1/20 0.32
CDK2 P24941 1/20 0.32
PTGS2 P35354 1/20 0.32
HPGD P15428 1/20 0.32
CES2 O00748 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8892569 0.80 L3MBTL1 (0.33) TSHRCYP1A2CYP2C9CYP2C19CNR2
SCHEMBL6224286 0.75 RAB9A (0.36) POLBALDH1A1TSHRCYP1A2CYP3A4
SCHEMBL28380710 0.73 AKR1C3 (0.50) POLBALDH1A1RAB9AAKR1C3HPGD
SCHEMBL8381457 0.70 RAB9A (0.38) POLBALDH1A1CYP1A2RAB9ACNR2
SCHEMBL5565829 0.69 AKR1C3 (0.48) POLBALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL6202434 0.67 CA12 (0.38) ALDH1A1TSHRCYP1A2CYP3A4CYP2C9
SCHEMBL28806438 0.67 PTGS2 (0.58) RAB9ACNR2NAAACCNE2CCNE1
SCHEMBL8332698 0.66 CA12 (0.46) ALDH1A1TSHRCYP1A2CYP3A4CYP2C9
SCHEMBL28428778 0.65 AKR1C3 (0.43) ALDH1A1TSHRABCB1CNR2NAAA
SCHEMBL28423660 0.65 RAB9A (0.51) POLBALDH1A1TSHRCYP1A2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1091953-A1 NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE G.D. Searle & Co. (US) 2001-04-18 EP disclosed
WO-2000001687-A1 BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE G.D. SEARLE & CO. (US) 2000-01-13 WO disclosed
WO-1997033882-A1 NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE G.D. SEARLE AND CO. (US) 1997-09-18 WO disclosed