Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Prazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP known ✓ | O00591 | 1/20 | 0.64 |
| ▸ | GABRD known ✓ | O14764 | 1/20 | 0.64 |
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.64 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.64 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.64 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.64 |
| ▸ | GABRA5 known ✓ | P31644 | 1/20 | 0.64 |
| ▸ | GABRA3 known ✓ | P34903 | 1/20 | 0.64 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.64 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.64 |
| ▸ | GABRA4 known ✓ | P48169 | 1/20 | 0.64 |
| ▸ | GABRE known ✓ | P78334 | 1/20 | 0.64 |
| ▸ | GABRA6 known ✓ | Q16445 | 1/20 | 0.64 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 1/20 | 0.64 |
| ▸ | GABRG3 known ✓ | Q99928 | 1/20 | 0.64 |
| ▸ | GABRQ known ✓ | Q9UN88 | 1/20 | 0.64 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.69 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Prazepam SCHEMBL29565880 | 1.00 | OPRK1 (0.69) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Prazepam SCHEMBL7617057 | 0.92 | OPRK1 (0.60) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Prazepam SCHEMBL4282434 | 0.89 | TP53 (0.60) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Prazepam SCHEMBL312369 | 0.88 | OPRK1 (0.72) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL11770839 | 0.88 | TP53 (0.69) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| SCHEMBL13352310 | 0.86 | TP53 (0.58) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Prazepam SCHEMBL18321926 | 0.86 | OPRK1 (0.54) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Prazepam SCHEMBL7537961 | 0.86 | LMNA (0.64) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Flutoprazepam SCHEMBL124578 | 0.86 | OPRK1 (0.67) | OPRK1NR1I2ADORA3OPRM1TP53 | |
| Flutoprazepam SCHEMBL29440278 | 0.86 | OPRK1 (0.67) | OPRK1NR1I2ADORA3OPRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 12583 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260092932-A1 | METHODS AND COMPOSITIONS FOR THE DETECTION, DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER | THE JOHNSON CENTER FOR CHILD HEALTH AND DEV (US) | 2026-04-02 | — | — | US | claimed |
| US-20260076953-A1 | METHODS OF DIAGNOSING AND TREATING ADHD IN BIOMARKER POSITIVE SUBJECTS | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2026-03-19 | — | — | US | claimed |
| US-20260027337-A1 | TRANSDERMAL DRUG DELIVERY DEVICES AND METHODS | MORNINGSIDE VENTURE INVESTMENTS LTD (MC) | 2026-01-29 | — | — | US | claimed |
| US-12515030-B2 | Transdermal drug delivery devices and methods | MORNINGSIDE VENTURE INVESTMENTS LIMITED (MC) | 2026-01-06 | — | — | US | claimed |
| US-20250375421-A1 | METHODS OF USING DMT | SHULMAN WILLIAM (US) | 2025-12-11 | — | — | US | claimed |
| EP-4622640-A1 | COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF | Brightseed, Inc. (US) | 2025-10-01 | — | — | EP | claimed |
| US-20250281451-A1 | COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND USES THEREOF | BRIGHTSEED, INC. | 2025-09-11 | — | — | US | claimed |
| US-12396981-B2 | Methods of using DMT | SHULMAN WILLIAM (US) | 2025-08-26 | — | — | US | claimed |
| WO-2025126159-A1 | A METHOD FOR TREATING A NEUROLOGICAL DISEASE IN A RECREATIONAL DRUG USER | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2025-06-19 | — | — | WO | claimed |
| US-20250179064-A1 | BENZOQUINOLONE INHIBITORS OF VMAT2 | AUSPEX PHARMACEUTICALS LLC | 2025-06-05 | — | — | US | claimed |
| EP-0216555-A2 | Use of dioxopiperidine derivatives in the treatment of anxiety, for the reduction of chronic abnormally high brain levels of serotonin or 5-hydroxy-indoleacetic acid, and in the treatment of bacterial or viral infections | BTG INTERNATIONAL LIMITED (GB) | 1987-04-01 | — | — | EP | claimed |
| EP-0098113-B1 | A COMBINATION OF BETA-ADRENOCEPTOR ANTAGONISTS AND ANXIOLYTIC AGENTS | AYERST, MCKENNA AND HARRISON INC. (CA) | 1986-09-03 | — | — | EP | claimed |
| US-4595684-A | Method of suppressing benzodiazepine induced sedation with 2-(p-methoxypenyl)-pyrazolo[4,3-c]quinolin-3(5H)-one or a salt thereof | CIBA-GEIGY CORPORATION (US) | 1986-06-17 | — | — | US | claimed |
| US-4557934-A | ALONG WITH A DIOL PYRROLIDONE OR AN AZACYCLOPENTAN-2-ONE | THE PROCTER & GAMBLE COMPANY (US) | 1985-12-10 | — | — | US | claimed |
| EP-0150721-A2 | Drug | Firma Paliz, Ziegler (CH) | 1985-08-07 | — | — | EP | claimed |
| EP-0098113-A1 | A combination of beta-adrenoceptor antagonists and anxiolytic agents | AYERST, MCKENNA AND HARRISON INC. (CA) | 1984-01-11 | — | — | EP | claimed |
| US-4316897-A | TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | claimed |
| EP-0025546-A2 | Therapeutical use of tranquillizing benzodiazepine derivatives and mixtures containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-03-25 | — | — | EP | claimed |
| US-4028467-A | Analgesic compositions comprising levo-propoxyphene and benzo diazepine and process | BERGER FRANK M | 1977-06-07 | — | — | US | claimed |
| US-4028466-A | Analgesic compositions comprising dextro-propoxyphene and benzodiazepine and process | BERGER FRANK M | 1977-06-07 | — | — | US | claimed |