Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 2/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6164646 | 0.74 | HTR1A (0.60) | TAAR1HTR6HTR2AHTR2CHTR2B | |
| SCHEMBL28847836 | 0.74 | SIGMAR1 (0.41) | HTR6HTR2ASIGMAR1ADRB1HTR3A | |
| Hydrochloric Acid SCHEMBL9654609 | 0.73 | HTR1A (0.59) | TAAR1HTR6HTR2AHTR2CHTR2B | |
| SCHEMBL6560078 | 0.70 | SIGMAR1 (0.68) | TAAR1HTR6SIGMAR1ADRB1HTR3A | |
| Hydrochloric Acid SCHEMBL2881381 | 0.69 | SIGMAR1 (0.66) | TAAR1HTR6SIGMAR1ADRB1HTR3A | |
| SCHEMBL13322698 | 0.69 | POLB (0.42) | HTR6HTR2AHTR2CSIGMAR1ADRB1 | |
| SCHEMBL9272777 | 0.69 | HTR6 (0.50) | TAAR1HTR6HTR2AHTR2CHTR2B | |
| SCHEMBL2875718 | 0.68 | ADRB1 (0.47) | HTR2CSIGMAR1ADRB1HTR3AHTR3E | |
| SCHEMBL13354917 | 0.68 | HTR2C (0.41) | HTR2CSIGMAR1ADRB1HTR3AHTR3E | |
| SCHEMBL3015461 | 0.68 | TAAR1 (0.50) | TAAR1HTR6SIGMAR1ADRB1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0732332-B1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | AVENTIS PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0732332-A1 | Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation | HOECHST MARION ROUSSEL, INC. (US) | 1996-09-18 | — | — | EP | disclosed |