Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OTUD7B | Q6GQQ9 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7823957 | 0.95 | ADRA2A (0.54) | ADRA2APRNPSMN1; SMN2BACE1PDE3B | |
| SCHEMBL7815545 | 0.83 | ALDH1A1 (0.40) | ADRA2ACHRNA7SMN1; SMN2 | |
| SCHEMBL743822 | 0.80 | ADRA2A (0.43) | ADRA2APRNPSMN1; SMN2BACE1PDE3B | |
| SCHEMBL9049906 | 0.79 | ADRA2A (0.55) | ADRA2APRNPCHRNA7SMN1; SMN2DRD2 | |
| SCHEMBL7824594 | 0.78 | ADRA2A (0.45) | ADRA2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7826706 | 0.78 | ADRA2A (0.54) | ADRA2ACHRNA7SMN1; SMN2DRD2DRD1 | |
| SCHEMBL9047053 | 0.73 | ADRA2A (0.55) | ADRA2APRNPCHRNA7SMN1; SMN2DRD2 | |
| Hydrochloric Acid SCHEMBL7830547 | 0.72 | ADRA2A (0.54) | ADRA2ACHRNA7SMN1; SMN2DRD2DRD1 | |
| SCHEMBL7828371 | 0.71 | ADRA2A (0.59) | ADRA2APRNPSMN1; SMN2DRD2DRD1 | |
| Hydrochloric Acid SCHEMBL7822802 | 0.70 | ADRA2A (0.57) | ADRA2APRNPSMN1; SMN2DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0712845-B1 | Amine compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-10-17 | — | — | EP | disclosed |
| US-5633248-A | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS, DIARYLALKYLIDENEDIAMINES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-05-27 | — | — | US | disclosed |
| US-5591849-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, INHIBITORS OF AMINE, AMINE OXIDASE B, AND CALCIUM ION UPTAKE, NEUROPATHY, DYSMNESIA | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-01-07 | — | — | US | disclosed |
| EP-0712845-A1 | Amine compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-05-22 | — | — | EP | disclosed |
| EP-0670313-A1 | Spiro compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-09-06 | — | — | EP | disclosed |