Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14500331 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL8809305 | 0.80 | KDM4E (0.58) | KDM4EALDH1A1HTTMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5419258 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL30767099 | 0.77 | NOTUM (0.59) | KDM4EALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL5696394 | 0.77 | NOTUM (0.59) | KDM4EALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL13349382 | 0.76 | ALDH1A1 (0.64) | KDM4EALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL5426108 | 0.76 | NOTUM (0.65) | ALDH1A1MAPTSMN1; SMN2GAATSHR | |
| SCHEMBL7830713 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL2289614 | 0.76 | SMN1; SMN2 (0.57) | KDM4EALDH1A1HTTMAPTSMN1; SMN2 | |
| SCHEMBL9208129 | 0.74 | NOTUM (0.57) | ALDH1A1SMN1; SMN2GAAL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114033-A1 | 4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | Pfizer Products Inc. (US) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000017166-A1 | 4-CARBOXYAMINO-2-METHYL-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS | PFIZER PRODUCTS INC. (US) | 2000-03-30 | — | — | WO | disclosed |