Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.57 |
| ▸ | AVPR2 | P30518 | 4/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.57 |
| ▸ | OXTR | P30559 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.53 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426108 | 0.94 | NOTUM (0.65) | NOTUMNPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL2116912 | 0.88 | NPC1 (0.71) | NOTUMNPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL29554766 | 0.88 | NPC1 (0.71) | NOTUMNPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL9530206 | 0.84 | NOTUM (0.62) | NOTUMAVPR2AVPR1AOXTRALDH1A1 | |
| SCHEMBL9312975 | 0.82 | BCHE (0.58) | NOTUMNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL9214372 | 0.82 | SMN1; SMN2 (0.68) | NOTUMALDH1A1SMN1; SMN2KMT2AGAA | |
| SCHEMBL24925819 | 0.81 | ALDH1A1 (0.62) | NOTUMAVPR2AVPR1AOXTRALDH1A1 | |
| SCHEMBL5795681 | 0.80 | NOTUM (0.57) | NOTUMAVPR2AVPR1AOXTRALDH1A1 | |
| SCHEMBL926908 | 0.79 | NOTUM (0.69) | NOTUML3MBTL1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL30039812 | 0.79 | NOTUM (0.69) | NOTUML3MBTL1ALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0487071-B1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-07-05 | — | — | EP | disclosed |
| US-5273974-A | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-28 | — | — | US | disclosed |
| EP-0487071-A1 | Condensed heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-05-27 | — | — | EP | disclosed |