Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LEF1 | Q9UJU2 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 2/20 | 0.54 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027522 | 0.86 | MMP13 (0.72) | LEF1MMP13MMP2KDM4EALDH1A1 | |
| SCHEMBL8985820 | 0.85 | MMP13 (0.68) | MMP13MMP2ROCK2KDM4EALDH1A1 | |
| SCHEMBL29783684 | 0.84 | PDGFRB (0.66) | LEF1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL22111129 | 0.84 | PDGFRB (0.66) | LEF1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6617416 | 0.83 | LEF1 (0.74) | LEF1MMP13MMP2KDM4EALDH1A1 | |
| SCHEMBL28681216 | 0.82 | KLK7 (0.46) | LEF1MMP13 | |
| SCHEMBL28681215 | 0.82 | KLK7 (0.46) | LEF1MMP13 | |
| SCHEMBL3030225 | 0.82 | LEF1 (0.60) | LEF1MMP13MMP2KDM4EALDH1A1 | |
| SCHEMBL20762188 | 0.81 | LEF1 (0.42) | LEF1MMP13MMP2ROCK2KDM4E | |
| SCHEMBL8985906 | 0.81 | SRD5A2 (0.60) | MMP13ROCK2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918752-A4 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RES INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0918752-A2 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RESEARCH, INC. (US) | 1999-06-02 | — | — | EP | disclosed |
| US-5843937-A | DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents | PANORAMA RESEARCH, INC. (US) | 1998-12-01 | — | — | US | disclosed |
| WO-1997044000-A2 | DNA-BINDING INDOLE DERIVATIVES, THEIR PRODRUGS AND IMMUNOCONJUGATES AS ANTICANCER AGENTS | PANORAMA RESEARCH, INC. (US) | 1997-11-27 | — | — | WO | disclosed |