SCHEMBL7834037

SCHEMBL7834037

CCCNS(=O)(=O)c1cc(O)ccc1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
GAA P10253 3/20 0.48
CA12 O43570 2/20 0.48
CA9 Q16790 2/20 0.48
TSHR P16473 2/20 0.48
TDP1 Q9NUW8 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.46
L3MBTL1 Q9Y468 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
SFRP1 Q8N474 1/20 0.44
MEP1B Q16820 1/20 0.43
ATM Q13315 1/20 0.43
LMNA P02545 2/20 0.43
HPGD P15428 1/20 0.43
HIF1A Q16665 1/20 0.43
HSD17B10 Q99714 1/20 0.43
GFER P55789 1/20 0.43
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8469458 0.91 CA12 (0.50) ALDH1A1GAACA12CA9TSHR
SCHEMBL9181456 0.88 RECQL (0.52) ALDH1A1GAACA12CA9TSHR
SCHEMBL9005826 0.87 ALDH1A1 (0.54) ALDH1A1GAATSHRTDP1SMN1; SMN2
SCHEMBL1685394 0.87 BRD4 (0.51) ALDH1A1GAATSHRTDP1SMN1; SMN2
SCHEMBL801417 0.83 TDP1 (0.62) ALDH1A1GAATSHRTDP1SMN1; SMN2
SCHEMBL22433208 0.81 CA12 (0.58) ALDH1A1CA12CA9TDP1SMN1; SMN2
SCHEMBL10913560 0.79 GAA (0.56) ALDH1A1GAATSHRSMN1; SMN2LMNA
SCHEMBL758273 0.78 TSHR (0.48) ALDH1A1GAATSHRTDP1SMN1; SMN2
SCHEMBL743630 0.78 LMNA (0.65) ALDH1A1GAATSHRSMN1; SMN2LMNA
SCHEMBL1032718 0.77 KDM4E (0.60) ALDH1A1GAACA12CA9TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1098891-A1 POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS Aventis Pharma Deutschland GmbH (DE) 2001-05-16 EP disclosed
WO-2000004006-A1 POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2000-01-27 WO disclosed