Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 3/20 | 0.33 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.33 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836031 | 0.85 | PDE7A (0.36) | MPOPDE7APDE7BXDHAHR | |
| SCHEMBL7824030 | 0.77 | SIRT1 (0.40) | AHR | |
| SCHEMBL7835174 | 0.77 | MAPT (0.42) | — | |
| SCHEMBL7835663 | 0.74 | AHR (0.53) | AHR | |
| SCHEMBL7835267 | 0.74 | ALDH1A1 (0.46) | AHR | |
| SCHEMBL7823203 | 0.70 | AHR (0.52) | AHR | |
| SCHEMBL7822873 | 0.70 | AHR (0.51) | AHR | |
| SCHEMBL7823266 | 0.69 | MAOA (0.52) | — | |
| SCHEMBL7824904 | 0.66 | AHR (0.40) | AHR | |
| SCHEMBL7834309 | 0.64 | AHR (0.51) | MPOXDHAHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109813-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012510-A1 | PYRROLOINDOLES, PYRIDOINDOLES AND AZEPINOINDOLES AS 5-HT2C AGONISTS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |