Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TK1 | P04183 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16653120 | 0.80 | TK1 (0.43) | BUB1TK1MAPK1TYMP | |
| SCHEMBL10953281 | 0.79 | GRIA1 (0.36) | GRIA1GRIA2GRIA4GRIK5HTT | |
| SCHEMBL8235112 | 0.79 | SQOR (0.49) | GRIA1GRIA2GRIA4GRIK5BUB1 | |
| SCHEMBL5334520 | 0.79 | TYMP (0.45) | THRBGRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL15616807 | 0.79 | LMNA (0.46) | GRIA1GRIA2GRIA4GRIK5BUB1 | |
| SCHEMBL4156346 | 0.79 | TYMP (0.45) | THRBGRIA1GRIA2GRIA4GRIK5 | |
| SCHEMBL7821308 | 0.77 | BUB1 (0.34) | THRBBUB1BCHETK1L3MBTL1 | |
| SCHEMBL20438154 | 0.76 | BUB1 (0.38) | THRBBUB1BCHEL3MBTL1MAPT | |
| SCHEMBL20445101 | 0.76 | BUB1 (0.38) | THRBBUB1BCHEL3MBTL1MAPT | |
| SCHEMBL7830622 | 0.73 | PIK3R1 (0.44) | BUB1BCHENPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0748800-B1 | Pyrimidinedione, pyrimidinetrione, triazinedione derivatives as alpha-1-adrenergic receptor antagonists | HOFFMANN LA ROCHE (CH) | 2001-05-09 | — | — | EP | disclosed |
| US-5859014-A | USEFUL IN TREATMENT OF DISEASES INVOLVING DIRECTLY OR INDIRECTLY AN OBSTRUCTION OF THE LOWER URINARY TRACT, SUCH ASBENIGN PROSTATE HYPERPLASIA | SYNTEX (U.S.A.) INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0748800-A2 | Pyrimidinedione, pyrimidinetrione, triazinedione, tetrahydroquinazolinedione derivatives as alpha-1-adrenergic receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-18 | — | — | EP | disclosed |