Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 11/20 | 0.57 |
| ▸ | PDK2 | Q15119 | 11/20 | 0.57 |
| ▸ | PDK3 | Q15120 | 11/20 | 0.57 |
| ▸ | PDK4 | Q16654 | 11/20 | 0.57 |
| ▸ | ABCC9 | O60706 | 10/20 | 0.53 |
| ▸ | ABCC8 | Q09428 | 10/20 | 0.53 |
| ▸ | KCNJ11 | Q14654 | 10/20 | 0.53 |
| ▸ | KCNJ8 | Q15842 | 10/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830341 | 0.94 | PDK1 (0.56) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7830042 | 0.85 | MET (0.56) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7835045 | 0.81 | PDK1 (0.48) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7833074 | 0.79 | PDK1 (0.56) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7833658 | 0.77 | PDK1 (0.46) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7832273 | 0.75 | PDK1 (0.46) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL28050469 | 0.74 | PDK1 (1.00) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL6359557 | 0.74 | PDK1 (1.00) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7833541 | 0.74 | LCK (0.68) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7832380 | 0.74 | ABCC9 (0.67) | PDK1PDK2PDK3PDK4ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0798288-B1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2001-05-16 | — | — | EP | disclosed |
| EP-0798288-A1 | TRICICLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1997-10-01 | — | — | EP | disclosed |