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SCHEMBL7834705

SCHEMBL7834705

CC(C)(C)OC(=O)NCC12CN(c3cc4c(cc3F)c(=O)c(C(=O)O)cn4C(C)(C)C(F)F)CC1CCO2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 10/20 0.40
▸ KDM4E B2RXH2 9/20 0.40
▸ HSD17B10 Q99714 7/20 0.39
▸ HPGD P15428 6/20 0.39
▸ LMNA P02545 6/20 0.39
▸ MAPT P10636 1/20 0.39
▸ DRD3 P35462 1/20 0.38
▸ HTT P42858 3/20 0.37
▸ TSHR P16473 2/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ TOP2A P11388 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ TOP2B Q02880 1/20 0.37
▸ BRD4 O60885 1/20 0.37
▸ CYP2J2 P51589 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.37
▸ MEN1 O00255 2/20 0.37
▸ KMT2A Q03164 2/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7847782 0.94 ALDH1A1 (0.41) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL7843329 0.93 ALDH1A1 (0.41) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL7494670 0.92 KDM4E (0.35) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL7844361 0.92 ALDH1A1 (0.40) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL8923588 0.89 KDM4E (0.53) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL7847367 0.87 ALDH1A1 (0.44) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL7847371 0.87 ALDH1A1 (0.44) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL8924069 0.86 LMNA (0.43) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL7502083 0.86 ALDH1A1 (0.36) ALDH1A1KDM4EHSD17B10HPGDLMNA
SCHEMBL7498541 0.85 ALDH1A1 (0.36) ALDH1A1KDM4EHSD17B10HPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20010036941-A1 Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolonecarboxylic acid and -naphthyridonecarboxylic acid derivatives for the therapy of Helicobacter pylori infections and associated gastroduodenal disorders PETERSEN UWE (DE) 2001-11-01 — — US disclosed
US-6288081-B1 Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith BAYER AKTIENGESELLSCHAFT (DE) 2001-09-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010036941-A1 Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo[3.3.0]oct-7-yl)-quinolonecarboxylic acid and -naphthyridonecarboxylic acid derivatives for the therapy of Helicobacter pylori infections and associated gastroduodenal disorders OXER1, AOC3, PAM ALDH1A1 670/4885KDM4E 1947/4885HSD17B10 707/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.