Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834869 | 0.85 | DHODH (0.59) | DHODHAGTR1AGTR2 | |
| SCHEMBL8501790 | 0.84 | PLA2G2A (0.52) | DHODHAGTR1AGTR2 | |
| SCHEMBL9119796 | 0.80 | DHODH (0.53) | DHODHAGTR1AGTR2KDM4E | |
| SCHEMBL237890 | 0.79 | RARB (0.51) | DHODHKDM4E | |
| SCHEMBL7835619 | 0.76 | PDE4A (0.41) | DHODHPDE10AAGTR1AGTR2 | |
| SCHEMBL235804 | 0.75 | RARB (0.52) | KDM4E | |
| SCHEMBL8780501 | 0.75 | MEN1 (0.42) | DHODHKDM4E | |
| SCHEMBL8673292 | 0.75 | KDM4E (0.55) | DHODHKDM4E | |
| SCHEMBL21065473 | 0.75 | KDM4E (0.51) | DHODHKDM4E | |
| SCHEMBL21065457 | 0.75 | KDM4E (0.51) | DHODHKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498723-B1 | Nitrogen containing bicycle compounds, method for their preparation, their use as pharmaceutical and compositions containing them | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | claimed |