Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.52 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.52 |
| ▸ | DHODH | Q02127 | 1/20 | 0.50 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834869 | 0.90 | DHODH (0.59) | AGTR1AGTR2DHODH | |
| SCHEMBL8505378 | 0.85 | PLA2G2A (0.52) | PLA2G2AAGTR1AGTR2DHODHLTB4R2 | |
| SCHEMBL7834873 | 0.84 | DHODH (0.47) | AGTR1AGTR2DHODH | |
| SCHEMBL8504880 | 0.83 | AGTR1 (0.60) | PLA2G2AAGTR1AGTR2DHODHLTB4R2 | |
| SCHEMBL8501923 | 0.80 | AGTR1 (0.50) | PLA2G2AAGTR1AGTR2LTB4R2ACHE | |
| SCHEMBL8671451 | 0.80 | PLA2G2A (0.50) | PLA2G2AAGTR1AGTR2DHODHLTB4R2 | |
| SCHEMBL9119796 | 0.80 | DHODH (0.53) | AGTR1AGTR2DHODH | |
| SCHEMBL8584304 | 0.79 | AGTR1 (0.49) | PLA2G2AAGTR1AGTR2LTB4R2ACHE | |
| SCHEMBL9176783 | 0.79 | AGTR1 (0.52) | PLA2G2AAGTR1AGTR2DHODHLTB4R2 | |
| SCHEMBL8501882 | 0.78 | MAPT (0.48) | PLA2G2AAGTR1AGTR2DHODHLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004979-A | ANGIOTENSIN II INHIBITORS; 4-((CARBOXY)ARYLOXY)-QUINOLINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |
| US-5817674-A | ANTIOTENSIN II RECEPTOR ANTAGONISTS | ROUSSEL UCLAF (FR) | 1998-10-06 | — | — | US | disclosed |