Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.57 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.57 |
| ▸ | BRS3 | P32247 | 2/20 | 0.54 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501790 | 0.90 | PLA2G2A (0.52) | DHODHAGTR1AGTR2 | |
| SCHEMBL7834873 | 0.85 | DHODH (0.47) | DHODHAGTR1AGTR2 | |
| SCHEMBL9119796 | 0.85 | DHODH (0.53) | DHODHAGTR1AGTR2 | |
| SCHEMBL9709750 | 0.84 | DHODH (0.59) | DHODHAGTR1AGTR2BRS3PPARG | |
| SCHEMBL8505737 | 0.83 | DHODH (0.55) | DHODHAGTR1AGTR2BRS3PPARG | |
| SCHEMBL8504852 | 0.82 | AGTR1 (0.56) | DHODHAGTR1AGTR2PPARG | |
| SCHEMBL8504620 | 0.80 | BRS3 (0.54) | DHODHAGTR1AGTR2BRS3 | |
| SCHEMBL9654571 | 0.79 | AGTR1 (0.56) | DHODHAGTR1AGTR2 | |
| SCHEMBL9709741 | 0.79 | KDM4E (0.57) | DHODHAGTR1AGTR2BRS3PPARG | |
| SCHEMBL3906504 | 0.78 | BRS3 (0.70) | DHODHAGTR1AGTR2BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0498723-B1 | Nitrogen containing bicycle compounds, method for their preparation, their use as pharmaceutical and compositions containing them | AVENTIS PHARMA SA (FR) | 2001-09-19 | — | — | EP | claimed |
| US-6004979-A | ANGIOTENSIN II INHIBITORS; 4-((CARBOXY)ARYLOXY)-QUINOLINE DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-12-21 | — | — | US | disclosed |