Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 7/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
| ▸ | MASP2 | O00187 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | CFD | P00746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629659 | 0.76 | KMT2A (0.57) | KDM4EPOLBKMT2AMEN1PKM | |
| SCHEMBL5169945 | 0.73 | ALDH1A1 (0.57) | KDM4EPOLBKMT2AMEN1PKM | |
| SCHEMBL29659875 | 0.73 | ALDH1A1 (0.57) | KDM4EPOLBKMT2AMEN1PKM | |
| SCHEMBL449366 | 0.72 | L3MBTL1 (0.58) | KDM4EPOLBKMT2AMEN1PKM | |
| SCHEMBL4749159 | 0.72 | DHODH (0.69) | KDM4EKMT2AMEN1PKMDHODH | |
| SCHEMBL13936398 | 0.72 | DHODH (0.64) | KDM4EPOLBKMT2AMEN1PKM | |
| SCHEMBL211260 | 0.72 | KMT2A (0.61) | KDM4EPOLBKMT2AMEN1PKM | |
| SCHEMBL29702265 | 0.71 | RXFP1 (0.55) | KDM4EPOLBKMT2AMEN1PKM | |
| SCHEMBL222446 | 0.71 | RXFP1 (0.55) | KDM4EPOLBKMT2AMEN1PKM | |
| SCHEMBL10489819 | 0.71 | KMT2A (0.63) | KDM4EPOLBKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109812-A2 | PYRROLOBENZODIAZEPINES | Spirogen Limited (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012508-A2 | PYRROLBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |