Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7365216 | 1.00 | LMNA (0.55) | LMNATDP1ITGB3ITGA2BITGAV | |
| SCHEMBL7375437 | 0.88 | GAA (0.48) | LMNATDP1F10ALDH1A1POLB | |
| SCHEMBL2633261 | 0.86 | LMNA (0.68) | LMNATDP1ITGB3ITGA2BALDH1A1 | |
| SCHEMBL7367468 | 0.86 | L3MBTL1 (0.48) | LMNATDP1ITGB3ITGA2BITGAV | |
| SCHEMBL4412296 | 0.78 | ITGB3 (0.48) | LMNATDP1ITGB3ITGA2BITGAV | |
| SCHEMBL4412293 | 0.78 | ITGB3 (0.48) | LMNATDP1ITGB3ITGA2BITGAV | |
| SCHEMBL13033926 | 0.77 | LMNA (0.56) | LMNATDP1ALDH1A1POLB | |
| SCHEMBL2735629 | 0.77 | LMNA (0.61) | LMNATDP1 | |
| SCHEMBL9716661 | 0.76 | LMNA (0.82) | LMNATDP1ALDH1A1POLB | |
| SCHEMBL9716658 | 0.76 | LMNA (0.82) | LMNATDP1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150997-A1 | COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | Elan Pharmaceuticals, Inc. (US) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000043415-A1 | COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 2000-07-27 | — | — | WO | disclosed |