Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7826411 | 0.86 | HTR6 (0.46) | HTR6MAPTALOX15GPR17HTR1A | |
| SCHEMBL12326581 | 0.83 | HTR6 (0.67) | HTR6MAPTHTR1ADRD2DRD4 | |
| SCHEMBL2204200 | 0.82 | HTR6 (0.53) | HTR6MAPTALOX15GPR17HTR1A | |
| SCHEMBL2202482 | 0.81 | GPR17 (0.57) | HTR6MAPTALOX15GPR17HTR1A | |
| SCHEMBL24074581 | 0.81 | ALDH1A1 (0.58) | MAPTALOX15GPR17GABRA1GABRB1 | |
| SCHEMBL8795754 | 0.80 | ALOX15 (0.61) | MAPTALOX15 | |
| SCHEMBL20535547 | 0.79 | ALOX15 (0.50) | MAPTALOX15GPR17GABRA1GABRB1 | |
| SCHEMBL28477589 | 0.79 | KDM4E (0.64) | HTR6MAPTALOX15GABRA1GABRB1 | |
| SCHEMBL7838931 | 0.79 | ALOX15 (0.46) | HTR6MAPTALOX15HTR1ADRD2 | |
| SCHEMBL7834192 | 0.79 | ALDH1A1 (0.60) | MAPTALOX15ALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147110-A1 | PYRAZINO(AZA)INDOLE DERIVATIVES | VERNALIS RESEARCH LIMITED (GB) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044753-A1 | PIRAZINO(AZA)INDOLE DERIVATIVES | VERNALIS RESEARCH LIMITED (GB) | 2000-08-03 | — | — | WO | disclosed |