Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839198 | 0.88 | RAB9A (0.64) | RAB9AMAPTGAAHDAC3HDAC4 | |
| SCHEMBL13501314 | 0.85 | MAPT (0.71) | RAB9AMAPTGAAMAOBHDAC3 | |
| SCHEMBL832694 | 0.82 | LTA4H (0.65) | SENP1LTA4HRAB9AMAPTGAA | |
| SCHEMBL1074012 | 0.81 | MAPT (0.68) | RAB9AMAPTGAAHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL8392031 | 0.81 | MAPT (0.77) | RAB9AMAPTGAAHDAC3HDAC4 | |
| SCHEMBL13850453 | 0.81 | SENP1 (0.68) | SENP1LTA4HRAB9AMAPTGAA | |
| SCHEMBL4628541 | 0.80 | MAPT (0.63) | LTA4HRAB9AMAPTGAAHDAC3 | |
| SCHEMBL23283414 | 0.80 | LTA4H (0.62) | SENP1LTA4HRAB9AMAOBSIRT2 | |
| SCHEMBL7827432 | 0.79 | PLAU (0.59) | RAB9AMAPTGAAHDAC3HDAC4 | |
| SCHEMBL1142086 | 0.79 | LTA4H (0.64) | SENP1LTA4HRAB9AMAOBNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1330638-A | Substituted benzo [ de ] isoquinoline-1, 3-diones | MERCK PATENT GMBH (DE) | 2002-01-09 | — | — | CN | disclosed |
| EP-1144381-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000032577-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-08 | — | — | WO | disclosed |