Sugi Predict

Sugi Predict / Compounds / SCHEMBL4628541

SCHEMBL4628541

SCHEMBL4628541

Nc1cccc(CCC(=O)Nc2ccc(Nc3ccccc3)cc2)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.63
▸ HTT P42858 1/20 0.63
▸ GAA P10253 3/20 0.62
▸ HDAC3 O15379 2/20 0.60
▸ HDAC4 P56524 2/20 0.60
▸ HDAC1 Q13547 2/20 0.60
▸ HDAC7 Q8WUI4 2/20 0.60
▸ HDAC2 Q92769 2/20 0.60
▸ HDAC10 Q969S8 2/20 0.60
▸ HDAC11 Q96DB2 2/20 0.60
▸ HDAC8 Q9BY41 2/20 0.60
▸ HDAC6 Q9UBN7 2/20 0.60
▸ HDAC9 Q9UKV0 2/20 0.60
▸ HDAC5 Q9UQL6 2/20 0.60
▸ ALDH1A1 P00352 4/20 0.55
▸ HPGD P15428 2/20 0.55
▸ TSHR P16473 1/20 0.54
▸ LTA4H P09960 1/20 0.53
▸ LMNA P02545 1/20 0.52
▸ RAB9A P51151 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13501314 0.94 MAPT (0.71) MAPTHTTGAAHDAC3HDAC4
SCHEMBL27671467 0.85 MAPT (0.86) MAPTHTTGAAHDAC3HDAC4
SCHEMBL1074012 0.85 MAPT (0.68) MAPTHTTGAAHDAC3HDAC4
SCHEMBL4625780 0.85 HDAC1 (0.55) MAPTHTTGAAHDAC3HDAC4
Hydrochloric Acid SCHEMBL8392031 0.85 MAPT (0.77) MAPTHTTGAAHDAC3HDAC4
SCHEMBL7827432 0.83 PLAU (0.59) MAPTHTTGAAHDAC3HDAC4
SCHEMBL7839198 0.82 RAB9A (0.64) MAPTHTTGAAHDAC3HDAC4
SCHEMBL307284 0.82 POLB (0.51) MAPTHTTGAAHDAC3HDAC4
SCHEMBL10198474 0.81 MAPT (0.77) MAPTHTTGAAHDAC3HDAC4
SCHEMBL7837786 0.80 SENP1 (0.62) MAPTHTTGAAHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1115720-B1 NOVEL N-(IMINOMETHYL)AMINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM SOD CONSEILS RECH APPLIC (FR) 2008-07-02 — — EP disclosed
US-7186752-B2 Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them SCRAS (FR) 2007-03-06 — — US disclosed
US-20050197329-A1 Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them SCRAS 2005-09-08 — — US disclosed
US-20050027009-A1 New derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them SOCIETE DE CONSEILS DE RECHERCHES D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) 2005-02-03 — — US disclosed
US-6809090-B2 NITROGEN MONOXIDE SYNTHASE AND/OR LIPIDIC PEROXIDATION INHIBITORS IPSEN PHARMA S.A.S. (FR) 2004-10-26 — — US disclosed
US-20040097494-A1 New derivatives of N-(iminomethy)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them SOCIETE DE CONSEILS DE RECHERCHES D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) 2004-05-20 — — US disclosed
CN-1144799-C N-(iminomethyl) amine derivatives, their preparation, their use as medicines and compositions containing them ��ѧ�о���Ӧ����ѯ��˾ 2004-04-07 — — CN disclosed
US-6620840-B1 Nitric oxide synthase inhibitors SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2003-09-16 — — US disclosed
US-6482822-B1 N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2002-11-19 — — US disclosed
CN-1335841-A N- (iminomethyl) amine derivatives, their preparation, their use as medicaments and pharmaceutical compositions containing them SOD CONSEILS RECH APPLIC (FR) 2002-02-13 — — CN disclosed
EP-1115720-A2 NOVEL N-(IMINOMETHYL)AMINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2001-07-18 — — EP disclosed
WO-2000017191-A2 N-(IMINOMETHYL)AMINE DERIVATIVES, THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2000-03-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050197329-A1 Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them NOS1, NOS2, NOS3 MAPT 633/4885HTT 1110/4885GAA 992/4885
US-20050027009-A1 New derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them NOS1, NOS2, NOS3 MAPT 744/4885HTT 1216/4885GAA 1122/4885
US-20040097494-A1 New derivatives of N-(iminomethy)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them NOS1, NOS2, NOS3 MAPT 629/4885HTT 1091/4885GAA 1464/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.