Buquineran

Buquineran

SCHEMBL783795

CCCCNC(=O)NC1CCN(c2ncnc3cc(OC)c(OC)cc23)CC1

nearest known ligand 0.60

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ENPP1 P22413 7/20 0.60
MAPK1 P28482 1/20 0.60
KDR P35968 3/20 0.55
PDGFRB P09619 7/20 0.54
ACHE P22303 1/20 0.53
BACE1 P56817 1/20 0.53
PDGFRA P16234 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11484522 0.89 ENPP1 (0.62) ENPP1MAPK1KDRPDGFRBACHE
SCHEMBL24391608 0.83 ENPP1 (0.67) ENPP1MAPK1PDGFRBACHEBACE1
SCHEMBL11494695 0.80 ENPP1 (0.59) ENPP1MAPK1PDGFRBACHEBACE1
SCHEMBL4966150 0.79 PDGFRB (0.70) ENPP1KDRPDGFRBACHEBACE1
SCHEMBL4965169 0.79 ENPP1 (0.61) ENPP1MAPK1PDGFRBACHEBACE1
SCHEMBL4969629 0.78 PDGFRA (0.60) ENPP1KDRPDGFRBACHEBACE1
SCHEMBL4966896 0.78 PDGFRA (0.57) ENPP1KDRPDGFRBPDGFRA
SCHEMBL4966832 0.78 PDGFRB (0.71) ENPP1KDRPDGFRBPDGFRA
SCHEMBL3072691 0.77 ENPP1 (0.57) ENPP1MAPK1PDGFRBACHEBACE1
SCHEMBL20814063 0.77 ENPP1 (0.68) ENPP1MAPK1PDGFRBACHEBACE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3621593-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES Cardix Therapeutics LLC (US) 2020-03-18 EP claimed
WO-2019194866-A1 DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES Cardix Therapeutics LLC (US) 2019-10-10 WO claimed
US-20190231786-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES CARDIX Therapeutics, LLC 2019-08-01 US claimed
CN-109890366-A Combination medicine for treating cardiovascular diseases and preparation and use methods thereof 美进医药公司 2019-06-14 CN claimed
US-20190070184-A1 DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES Cardix Therapeutics LLC (US) 2019-03-07 US claimed
WO-2018208723-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES Cardix Therapeutics LLC (US) 2018-11-15 WO claimed
US-20180325907-A1 PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES CARDIX Therapeutics, LLC 2018-11-15 US claimed
CN-101330905-A Freeze-drying process and products obtained thereby SCIDOSE LLC (US) 2008-12-24 CN claimed
US-6297243-B1 TREATING OSTEOPENIA THAT ACCOMPANIES THE MENOPAUSE NOVO NORDISK A/S (DK) 2001-10-02 US claimed
JP-2001500865-A 2001-01-23 JP claimed
EP-0961616-A4 NON-HORMONAL METHOD OF CONTRACEPTION TRUSTEES OF BOARD OF (US) 2000-11-22 EP claimed
US-6110471-A ADMINISTERING PHOSPHODIESTERASE FOR INHIBITION OF THE CYCLES THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2000-08-29 US claimed
EP-1028690-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 2000-08-23 EP claimed
EP-0961616-A1 NON-HORMONAL METHOD OF CONTRACEPTION THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1999-12-08 EP claimed
WO-1999020223-A2 LUTEINISING HORMONE ANTAGONISTS USEFUL FOR TREATMENT OF ESTROGEN DEFICIENCIES, OR AS A CONTRACEPTIVE NOVO NORDISK A/S (DK) 1999-04-29 WO claimed
WO-1998010765-A1 NON-HORMONAL METHOD OF CONTRACEPTION THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 1998-03-19 WO claimed
EP-4109850-B1 CONTROL PLANE BASED CONFIGURATION FOR TIME SENSITIVE NETWORKING TOYOTA MOTOR CO LTD (JP) 2026-05-20 EP disclosed
US-12587440-B2 Stateful management of network device configurations CISCO TECHNOLOGY, INC. (US) 2026-03-24 US disclosed
US-4489075-A Cyclic sulfonamidoalkyl substituted 4-piperidinoquinazoline cardiac stimulants PFIZER INC. (US) 1984-12-18 US disclosed
EP-0094766-A2 Quinazoline cardiac stimulants Pfizer Limited (GB) 1983-11-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12587440-B2 Stateful management of network device configurations LGMN, TRRAP, CTCF ENPP1 4419/4885MAPK1 2938/4885KDR 4316/4885
US-20190070184-A1 DEUTERATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATING CARDIOVASCULAR DISEASES ADRB2, ADRA2C, ADRB1 ENPP1 1218/4885MAPK1 3085/4885KDR 1096/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.