Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 7/20 | 0.51 |
| ▸ | PPARG | P37231 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7603000 | 0.94 | PPARA (0.59) | PPARAPPARG | |
| SCHEMBL9572629 | 0.90 | ALOX5 (0.45) | PPARAPPARGMTNR1AMTNR1BCHRM2 | |
| SCHEMBL2093439 | 0.82 | SOD1 (0.50) | — | |
| SCHEMBL1788069 | 0.80 | PPARA (0.51) | PPARAPPARG | |
| SCHEMBL2096581 | 0.79 | THRB (0.47) | CHRM2CHRM1CHRM3 | |
| SCHEMBL145383 | 0.79 | CHRM2 (0.65) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL7839636 | 0.78 | PPARA (0.52) | PPARAPPARGCYP2D6MTNR1AMTNR1B | |
| SCHEMBL29209337 | 0.78 | PPARA (0.52) | PPARAPPARGCYP2D6 | |
| SCHEMBL29648269 | 0.78 | PLK1 (0.57) | PPARAPPARGCYP2D6 | |
| SCHEMBL8986274 | 0.77 | PPARA (0.59) | PPARAPPARGCYP2D6CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454501-B1 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | SANKYO CO (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0839812-A1 | Preparation of benzylthiazolidine derivatives | Sankyo Company Limited (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5387596-A | Treating arteriosclerosis | SANKYO COMPANY, LIMITED (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0454501-A2 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | Sankyo Company Limited (JP) | 1991-10-30 | — | — | EP | disclosed |