Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 9/20 | 0.34 |
| ▸ | MMP3 | P08254 | 7/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940058 | 0.91 | CTSK (0.38) | MMP1MMP13MMP2MMP3 | |
| SCHEMBL7840445 | 0.86 | MMP1 (0.46) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6983815 | 0.84 | MMP1 (0.41) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6940169 | 0.83 | ADAM17 (0.45) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6986871 | 0.83 | MMP1 (0.37) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL4290067 | 0.81 | MMP2 (0.41) | MMP1MMP2MMP3 | |
| SCHEMBL6982858 | 0.80 | MMP1 (0.38) | MMP1MMP13REN | |
| SCHEMBL6221034 | 0.80 | MMP1 (0.38) | MMP1MMP13MMP2MMP3APP | |
| SCHEMBL6941577 | 0.79 | MMP1 (0.50) | MMP1MMP13MMP2MMP3 | |
| SCHEMBL6982289 | 0.79 | MMP1 (0.37) | MMP1MMP13APPREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993442-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-04-23 | — | — | EP | disclosed |
| US-6235787-B1 | ANTIINFLAMMATORY AGENTS; RHEUMATIC DISEASES; BONE DISORDERS; SKIN DISORDERS; MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. | 2001-05-22 | — | — | US | disclosed |