Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306804 | 0.90 | RAB9A (0.65) | POLBRAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL7839418 | 0.86 | BACE1 (0.54) | ALDH1A1MAPTHPGDRAB9ANPC1 | |
| SCHEMBL4666943 | 0.78 | LMNA (0.73) | MAPTRAB9ANPC1MEN1KMT2A | |
| SCHEMBL14886137 | 0.78 | MAPT (0.67) | ALDH1A1MAPTPOLBHPGDMEN1 | |
| SCHEMBL306284 | 0.77 | SMN1; SMN2 (0.66) | ALDH1A1MAPTRAB9ANPC1MEN1 | |
| SCHEMBL2008813 | 0.77 | ALDH1A1 (0.70) | ALDH1A1MAPTPOLBHPGDRAB9A | |
| SCHEMBL13501314 | 0.76 | MAPT (0.71) | ALDH1A1MAPTHPGDRAB9AKMT2A | |
| SCHEMBL7827432 | 0.76 | PLAU (0.59) | ALDH1A1MAPTPOLBHPGDRAB9A | |
| SCHEMBL1074012 | 0.75 | MAPT (0.68) | ALDH1A1MAPTPOLBHPGDRAB9A | |
| SCHEMBL7828031 | 0.75 | KMT2A (0.59) | ALDH1A1MAPTPOLBRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144381-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000032577-A2 | SUBSTITUTED BENZO[DE]ISOQUINOLINE-1,3-DIONES | MERCK PATENT GMBH (DE) | 2000-06-08 | — | — | WO | disclosed |