Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8162240 | 0.78 | TACR1 (0.45) | ALDH1A1DRD2DRD4 | |
| SCHEMBL7829838 | 0.77 | PKLR (0.48) | POLBALDH1A1 | |
| SCHEMBL7841109 | 0.76 | TGFBR1 (0.45) | KIF18A | |
| SCHEMBL5170560 | 0.69 | NR3C1 (0.40) | TYRO3POLBALDH1A1SMN1; SMN2ROCK1 | |
| SCHEMBL10210711 | 0.69 | BRD4 (0.51) | POLBALDH1A1SMN1; SMN2ROCK1ROCK2 | |
| Hydrochloric Acid SCHEMBL7841619 | 0.68 | KMT2A (0.44) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL1177815 | 0.68 | FFAR1 (0.44) | — | |
| SCHEMBL7839369 | 0.68 | SSTR4 (0.49) | POLBALDH1A1SSTR1SSTR4 | |
| SCHEMBL7840409 | 0.67 | SSTR4 (0.42) | POLBALDH1A1SMN1; SMN2SSTR1SSTR4 | |
| Hydrochloric Acid SCHEMBL7832311 | 0.67 | SSTR4 (0.50) | POLBALDH1A1SSTR1SSTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944388-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0944388-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1997038665-A2 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-23 | — | — | WO | disclosed |