Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.47 |
| ▸ | SNCA | P37840 | 2/20 | 0.47 |
| ▸ | ALPL | P05186 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26094639 | 0.86 | MAP2K4 (0.56) | MAPTRAB9ANPC1MAPK1ALPL | |
| SCHEMBL26915274 | 0.85 | MAPT (0.46) | RAF1MAPTRAB9ANPC1MAPK1 | |
| SCHEMBL14985491 | 0.84 | GAA (0.63) | MAPTRAB9ANPC1MAPK1ALPL | |
| SCHEMBL8364912 | 0.82 | KMT2A (0.54) | RAF1MAPTRAB9ANPC1MAPK1 | |
| SCHEMBL17279929 | 0.82 | PRKD1 (0.54) | RAF1MAPTRAB9ANPC1MAPK1 | |
| SCHEMBL26915302 | 0.81 | MAPT (0.50) | MAPTRAB9ANPC1MAPK1ALPL | |
| SCHEMBL9976034 | 0.80 | RAB9A (0.77) | MAPTRAB9ANPC1MAPK1ALPL | |
| SCHEMBL14872141 | 0.80 | LMNA (0.52) | MAPTLMNAKDM4E | |
| SCHEMBL13063663 | 0.79 | LMNA (0.56) | MAPTLMNA | |
| SCHEMBL2271347 | 0.79 | LMNA (0.56) | MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150958-A1 | SUBSTITUTED PYRAZOLE CARBOXYLIC ACIDS USED TO COMBAT ANAEMIAS | Bayer Aktiengesellschaft (DE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046208-A1 | SUBSTITUTED PYRAZOLE CARBOXYLIC ACIDS USED TO COMBAT ANAEMIAS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-08-10 | — | — | WO | disclosed |