Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843828 | 0.89 | CCR3 (0.52) | HTR2AHTR2CCCR3KDM4EKIF11 | |
| SCHEMBL7844479 | 0.83 | HTR6 (0.50) | KEAP1NFE2L2HTR2AHTR2CHTR6 | |
| SCHEMBL7842995 | 0.81 | HTR6 (0.51) | HTR2AHTR2CHTR7HTR6SMN1; SMN2 | |
| SCHEMBL7808827 | 0.80 | L3MBTL1 (0.41) | HTR2AHTR6OPRM1OPRD1OPRK1 | |
| SCHEMBL6640509 | 0.80 | HTR2A (0.47) | HTR2AHTR2CGAAHTTNPC1 | |
| SCHEMBL7842572 | 0.74 | TRPM8 (0.54) | SMN1; SMN2LMNAKDM4EALDH1A1GAA | |
| SCHEMBL5793597 | 0.71 | SLC6A4 (0.56) | HTR2AHTR2CHTR7HTR6OPRM1 | |
| SCHEMBL4078326 | 0.71 | PARP1 (0.48) | HTR2AHTR2CHTR6CCR3 | |
| Ethylene SCHEMBL6638987 | 0.69 | SLC6A4 (0.54) | HTR2AHTR2CHTR7HTR6OPRM1 | |
| SCHEMBL4103222 | 0.69 | KDM4E (0.41) | KEAP1NFE2L2HTR2AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |