Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841718 | 0.89 | KEAP1 (0.47) | CCR3HTR2AHTR2CKDM4EFEN1 | |
| SCHEMBL6640509 | 0.80 | HTR2A (0.47) | HTR2AKCNH2HTR2C | |
| SCHEMBL7842995 | 0.73 | HTR6 (0.51) | HTR2AHTR2CMEN1KMT2AKDM4E | |
| SCHEMBL7844479 | 0.72 | HTR6 (0.50) | CCR3HTR2AHTR2C | |
| SCHEMBL7808827 | 0.72 | L3MBTL1 (0.41) | HTR2AMEN1KMT2APARP1 | |
| SCHEMBL6636763 | 0.71 | DRD2 (0.57) | HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL4078326 | 0.71 | PARP1 (0.48) | CCR3HTR2AKCNH2HTR2CDRD2 | |
| SCHEMBL11830644 | 0.71 | PTGDR2 (0.38) | — | |
| SCHEMBL22156473 | 0.70 | SLC6A4 (0.42) | CCR3HTR2AHTR2CKMT2A | |
| Ethylene SCHEMBL7483250 | 0.69 | DRD2 (0.55) | HTR2AKCNH2HTR2CDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |