Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.51 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22773274 | 0.84 | HTR6 (0.70) | HTR6MAPKAPK2ALDH1A1HPGDKDM4E | |
| SCHEMBL7842572 | 0.81 | TRPM8 (0.54) | MAPKAPK2ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL7841718 | 0.81 | KEAP1 (0.47) | HTR6ALDH1A1KDM4EHSD17B10HTR7 | |
| Hydrochloric Acid SCHEMBL5375438 | 0.81 | MCHR1 (0.52) | HTR6MAPKAPK2ALDH1A1HPGDKDM4E | |
| SCHEMBL7808827 | 0.78 | L3MBTL1 (0.41) | HTR6MEN1KMT2AHTR2A | |
| SCHEMBL6640509 | 0.77 | HTR2A (0.47) | HTR2AHTR2CGAA | |
| SCHEMBL6634309 | 0.75 | IDO1 (0.58) | HTR6MAPTTSHRMTNR1AMTNR1B | |
| SCHEMBL7843828 | 0.73 | CCR3 (0.52) | KDM4EMEN1KMT2AHTR2AHTR2C | |
| SCHEMBL11632616 | 0.73 | HTR6 (0.56) | HTR6ALDH1A1HPGDKDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL11847410 | 0.72 | HTR6 (0.55) | HTR6ALDH1A1HPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |