SCHEMBL7841786

SCHEMBL7841786

CCCCCCOCCOc1ccc2cc(-c3ncc(O)cn3)ccc2c1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RARB P10826 4/20 0.47
NR5A1 Q13285 1/20 0.47
SPHK2 Q9NRA0 7/20 0.45
NPC1 O15118 3/20 0.45
RAB9A P51151 3/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
HSD17B10 Q99714 1/20 0.45
KDM4E B2RXH2 1/20 0.45
THRA P10827 1/20 0.44
SPHK1 Q9NYA1 5/20 0.43
MAPT P10636 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7835844 0.96 RARB (0.50) RARBSPHK2NPC1RAB9ASMN1; SMN2
SCHEMBL7837947 0.94 NR5A1 (0.53) RARBNR5A1SPHK2NPC1RAB9A
SCHEMBL7842632 0.94 NR5A1 (0.53) RARBNR5A1SPHK2NPC1RAB9A
SCHEMBL7838004 0.89 NPC1 (0.51) RARBNPC1SMN1; SMN2MAPT
SCHEMBL7838812 0.89 NPC1 (0.51) RARBNPC1SMN1; SMN2MAPT
SCHEMBL7838536 0.85 ALOX5 (0.44) RARBSPHK2NPC1RAB9ASMN1; SMN2
SCHEMBL7883583 0.83 NPC1 (0.63) RARBNR5A1NPC1RAB9ASMN1; SMN2
SCHEMBL7506953 0.82 NPC1 (0.65) RARBNR5A1NPC1RAB9ASMN1; SMN2
SCHEMBL7877116 0.82 NPC1 (0.65) RARBNR5A1NPC1RAB9ASMN1; SMN2
SCHEMBL9513828 0.82 NPC1 (0.65) RARBNR5A1NPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0751133-B1 Pyrimidine compound, and liquid crystal composition and liquid crystal element using the same MITSUI CHEMICALS INC (JP) 2001-09-12 EP disclosed
US-5770108-A HIGH SPEED RESPONSE, MOLECULAR ORIENTATION, HIGH CONTRAST, RECEPTIVITY MITSUI TOATSU CHEMICALS, INC. (JP) 1998-06-23 US disclosed
EP-0751133-A1 Pyrimidine compound, and liquid crystal composition and liquid crystal element using the same MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1997-01-02 EP disclosed