Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.63 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002265 | 0.88 | HTR2A (0.73) | GPR84HTR2AADRB3SLC6A4ADRB1 | |
| SCHEMBL1304961 | 0.88 | HTR2A (0.73) | GPR84HTR2AADRB3SLC6A4ADRB1 | |
| SCHEMBL3182374 | 0.87 | GPR84 (0.67) | GPR84HTR2AADRB3SLC6A4ADRB1 | |
| SCHEMBL24328361 | 0.82 | SMN1; SMN2 (0.67) | GPR84HTR2AADRB3SLC6A4 | |
| SCHEMBL5149322 | 0.79 | GPR84 (0.59) | GPR84HTR2AADRB3SLC6A4ADRB1 | |
| SCHEMBL25139528 | 0.79 | GPR84 (0.59) | GPR84HTR2AADRB3SLC6A4 | |
| SCHEMBL7997808 | 0.79 | HTR2A (0.62) | GPR84HTR2AADRB3HTR1AHTR2C | |
| SCHEMBL10079015 | 0.79 | HTR2A (0.57) | GPR84HTR2AADRB3SLC6A4HTR1A | |
| SCHEMBL3195765 | 0.78 | GPR84 (0.73) | GPR84HTR2AADRB3SLC6A4 | |
| SCHEMBL18399535 | 0.78 | GPR84 (0.63) | GPR84HTR2AADRB3SLC6A4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |