Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.55 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6441257 | 0.74 | ITGB3 (0.75) | LMNAITGB3ITGA2BTP53SMN1; SMN2 | |
| SCHEMBL609722 | 0.71 | ITGB3 (1.00) | ITGB3ITGA2B | |
| SCHEMBL7834338 | 0.70 | HPN (0.48) | LMNASMN1; SMN2 | |
| SCHEMBL7422985 | 0.70 | ITGB3 (0.78) | LMNAITGB3ITGA2BTP53 | |
| SCHEMBL2521926 | 0.63 | SMN1; SMN2 (0.80) | LMNATP53SMN1; SMN2THRBPOLB | |
| SCHEMBL7842067 | 0.63 | ITGB3 (0.55) | ITGB3ITGA2B | |
| SCHEMBL12210642 | 0.61 | PKM (0.61) | LMNATP53SMN1; SMN2THRBPOLB | |
| SCHEMBL12210575 | 0.61 | SMN1; SMN2 (0.59) | LMNATP53SMN1; SMN2THRBPOLB | |
| SCHEMBL2534800 | 0.61 | SMN1; SMN2 (0.62) | LMNATP53SMN1; SMN2THRBPOLB | |
| SCHEMBL12210685 | 0.61 | HDAC6 (0.52) | LMNATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1023295-A4 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO INC (US) | 2001-01-24 | — | — | EP | disclosed |
| EP-1023295-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | Merck & Co., Inc. (US) | 2000-08-02 | — | — | EP | disclosed |
| US-5981584-A | USEFUL IN THE MANUFACTURE OF A MEDICAMENT FOR INHIBITING THE AGGREGATION OF BLOOD PLATELETS, INHIBITING ANGIOGENESIS, INHIBITING OSTEOCLAST MEDIATED BONE RESORPTION, PREVENTING PLATELET THROMBOSIS | MERCK & CO., INC. (US) | 1999-11-09 | — | — | US | disclosed |
| WO-1998034935-A1 | FIBRINOGEN RECEPTOR ANTAGONIST PRODRUGS | MERCK & CO., INC. (US) | 1998-08-13 | — | — | WO | disclosed |