Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR5A | P47898 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8039622 | 0.77 | GRM5 (0.42) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7851700 | 0.75 | KDM4E (0.54) | DRD2DRD1DRD5DRD3KDM4E | |
| SCHEMBL14345729 | 0.70 | DRD2 (0.43) | DRD2DRD1DRD5DRD3MAOA | |
| SCHEMBL7843326 | 0.69 | NOTUM (0.47) | DRD2DRD1DRD5DRD3MAOA | |
| SCHEMBL14345923 | 0.69 | KDM4E (0.44) | DRD2DRD1DRD5DRD3MAOA | |
| SCHEMBL4699104 | 0.68 | KDM4E (0.47) | DRD2DRD1DRD5DRD3MAOA | |
| SCHEMBL11818033 | 0.67 | DRD2 (0.45) | DRD2DRD1DRD5DRD3MAOA | |
| SCHEMBL1990706 | 0.66 | DRD1 (0.55) | DRD2DRD1DRD5DRD3MAOA | |
| SCHEMBL1988107 | 0.65 | KDM4E (0.43) | DRD2DRD1DRD5DRD3MAOA | |
| SCHEMBL18537065 | 0.65 | ALDH1A1 (0.43) | DRD2DRD1DRD5DRD3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | disclosed |