Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78162 | 0.85 | L3MBTL1 (0.39) | L3MBTL1RAPGEF4HTTPOLBALDH1A1 | |
| SCHEMBL22454710 | 0.84 | RAPGEF4 (0.34) | L3MBTL1RAPGEF4HTTPDK2 | |
| SCHEMBL10256479 | 0.83 | ALDH1A1 (0.40) | RAPGEF4POLBALDH1A1CA2TYR | |
| SCHEMBL91357 | 0.82 | L3MBTL1 (0.34) | L3MBTL1RAPGEF4HTT | |
| SCHEMBL14130876 | 0.82 | RIPK1 (0.32) | POLBAPEX1 | |
| SCHEMBL12597845 | 0.79 | L3MBTL1 (0.43) | L3MBTL1RAPGEF4HTTPOLBALDH1A1 | |
| SCHEMBL21718397 | 0.78 | CYP3A4 (0.41) | POLBALDH1A1CA2APEX1 | |
| SCHEMBL21718952 | 0.77 | NR1H4 (0.37) | — | |
| SCHEMBL18957772 | 0.76 | RAPGEF4 (0.39) | L3MBTL1RAPGEF4POLBALDH1A1CA2 | |
| SCHEMBL21718954 | 0.75 | NR1H4 (0.37) | RAPGEF4HTTPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |