Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL78435 | 0.82 | L3MBTL1 (0.35) | L3MBTL1RAPGEF4HTT | |
| SCHEMBL20089652 | 0.81 | RAPGEF4 (0.33) | RAPGEF4 | |
| SCHEMBL22454710 | 0.76 | RAPGEF4 (0.34) | L3MBTL1RAPGEF4HTT | |
| SCHEMBL19833099 | 0.74 | ESR1 (0.31) | — | |
| SCHEMBL17552753 | 0.74 | RIPK1 (0.33) | — | |
| SCHEMBL78162 | 0.73 | L3MBTL1 (0.39) | L3MBTL1RAPGEF4HTTTSHR | |
| SCHEMBL10256479 | 0.70 | ALDH1A1 (0.40) | RAPGEF4TSHR | |
| SCHEMBL91339 | 0.68 | RAPGEF4 (0.33) | L3MBTL1RAPGEF4TSHR | |
| SCHEMBL20091626 | 0.67 | RIPK1 (0.36) | — | |
| SCHEMBL12597845 | 0.67 | L3MBTL1 (0.43) | L3MBTL1RAPGEF4HTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |