Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843292 | 0.84 | CES2 (0.43) | KMT2AMEN1NPC1RAB9ACES2 | |
| SCHEMBL7840807 | 0.84 | RAB9A (0.47) | KMT2AMEN1NPC1RAB9ACES2 | |
| SCHEMBL7845030 | 0.80 | AKR1C3 (0.46) | KMT2AMEN1NPC1RAB9ACES2 | |
| SCHEMBL7147778 | 0.78 | TYK2 (0.50) | NPC1RAB9ACES2CES1SLC6A2 | |
| Bromide SCHEMBL6280875 | 0.77 | TYK2 (0.49) | NPC1RAB9ACES2CES1SLC6A2 | |
| SCHEMBL10889643 | 0.76 | CES2 (0.48) | KMT2AMEN1CES2CES1LMNA | |
| SCHEMBL6516239 | 0.75 | PLK1 (0.42) | KMT2AMEN1CES2CES1LMNA | |
| SCHEMBL7843096 | 0.75 | PLK1 (0.42) | KMT2AMEN1CES2CES1LMNA | |
| SCHEMBL7833587 | 0.75 | PLK1 (0.42) | KMT2AMEN1CES2CES1MAPT | |
| SCHEMBL28629683 | 0.73 | SLC6A2 (0.49) | NPC1RAB9AHPGDSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |