Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843300 | 0.86 | CES2 (0.41) | NPC1RAB9AMAPTTP53MEN1 | |
| SCHEMBL7840811 | 0.86 | RAB9A (0.39) | ELANEPLAUNPC1RAB9AMAPT | |
| SCHEMBL7845037 | 0.82 | DAO (0.40) | NPC1RAB9ADAOMEN1LMNA | |
| SCHEMBL7843105 | 0.78 | NPC1 (0.38) | NPC1RAB9ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7833590 | 0.77 | ALDH1A1 (0.38) | SLC6A3DAOHPGDMEN1LMNA | |
| SCHEMBL7842196 | 0.77 | CES2 (0.46) | NPC1RAB9ADAOHPGDMAPT | |
| SCHEMBL7843947 | 0.73 | CES2 (0.41) | NPC1RAB9ADAOHPGD | |
| SCHEMBL7847644 | 0.73 | CES2 (0.44) | NPC1RAB9ASLC6A2SLC6A3HPGD | |
| SCHEMBL28629683 | 0.71 | SLC6A2 (0.49) | ELANEPLAUNPC1RAB9ASLC6A2 | |
| SCHEMBL7846601 | 0.71 | ALDH1A1 (0.49) | NPC1RAB9AMAPTTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |