Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.44 |
| ▸ | CES1 | P23141 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7843300 | 0.85 | CES2 (0.41) | CES2CES1MAPTKDM4EMEN1 | |
| SCHEMBL7508732 | 0.82 | NPC1 (0.36) | CES2CES1KDM4EMEN1KMT2A | |
| SCHEMBL7847644 | 0.78 | CES2 (0.44) | CES2CES1MAPTKDM4EMEN1 | |
| SCHEMBL7843738 | 0.76 | ELANE (0.38) | MAPTMEN1KMT2ANPC1TP53 | |
| SCHEMBL7840811 | 0.74 | RAB9A (0.39) | CES2CES1MAPTKDM4EMEN1 | |
| SCHEMBL7833590 | 0.74 | ALDH1A1 (0.38) | CES2CES1MEN1KMT2AALDH1A1 | |
| SCHEMBL6518724 | 0.73 | CES2 (0.57) | CES2CES1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL7845037 | 0.73 | DAO (0.40) | CES2CES1MEN1KMT2AALDH1A1 | |
| SCHEMBL14829993 | 0.72 | CES2 (0.61) | CES2CES1KDM4EALDH1A1NPC1 | |
| SCHEMBL7843105 | 0.71 | NPC1 (0.38) | CES2CES1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1125932-A2 | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2001-08-22 | — | — | EP | disclosed |
| US-5668161-A | Substituted thiazoles for the treatment of inflammation | G.D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | disclosed |